We do not retain these email addresses. COVID-19 is an emerging, rapidly evolving situation. BMC Med Genomics. There, this cancer, affecting a silver-dollar-sized region at the back of the nose, is the leading cancer … Many cases of nasopharygeal cancer are not preventable, but taking these steps may help lower your risk of nasopharyngeal cancer: Avoid salt-cured fish and meats. Cancer Res. American Journal of Cancer ISSN: 0099-7374, Sign In to Email Alerts with your Email Address. Background Despite salted fish being a classical risk factor of Nasopharyngeal Carcinoma (NPC), whether secular trends in salted fish consumption worldwide accounted for changes in NPC rates … It is estimated that over 90% of young nasopharyngeal carcinoma cases in Hong Kong Chinese can be attributed to consumption of this food during childhood.  |  Relationship Between Salted Fish Consumption and Nasopharyngeal Carcinoma: An Evidence-based Case Report. People who were fed salt-cured fish when they were children, especially … This site needs JavaScript to work properly. Still, EBV infection rarely leads to NPC, so other factors probably play a role in whether or not it causes cancer. NLM 2019 Jan 15;12(1):9. doi: 10.1186/s12920-018-0465-4. Enter multiple addresses on separate lines or separate them with commas. Nasopharyngeal (nay-zoh-fuh-RIN-jee-ul) carcinoma is cancer that occurs in the nasopharynx, which is located behind your nose and above the back of your throat.Nasopharyngeal carcinoma is rare in the United States. However, results for adult intakes of salted fish and preserved … Figure 8 RR (95% CI) of nasopharyngeal cancer for the highest compared with the lowest level of salted fish intake during adulthood .....39 Figure 9 Relative risk of nasopharyngeal cancer for 1 time per week increase of salted fish Nasopharyngeal cancer is related to the race (the morbidity of the yellow is higher than that of the white) and genetic factor. ↵1 Supported in part by Grants CA00884 from the National Cancer Institute and SIG-2 from the American Cancer Society, donations from Mr. Wong Hoo Chuen of Hong Kong, and the Hong Kong Anti-Cancer Society. Copyright © 2021 by the American Association for Cancer Research. How to Prevent? And on the list of Group 1 carcinogens is Chinese-style salted fish, which is known to cause nasopharyngeal cancer - which is related to the upper part of the throat behind the nose. Renaud S, Lefebvre A, Mordon S, Moralès O, Delhem N. Int J Mol Sci. … Occupational exposure to smokes (relative risk, 6.0; p = 0.006) and to dusts (relative risk, 4.0; p less than 0.001) was also significantly associated with nasopharyngeal carcinoma. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Although rare in most other parts of the world, nasopharyngeal carcinoma (NPC) is a common malignancy in southern China, especially for the Cantonese who inhabit the central region of Guangdong Province (National Cancer Control Office, 1979; Yu et al., 1981).Ingestion of Chinese salted fish … 1998;77:228–35. of salted fish and EBV was strongly associated with NPC, and more so than EBV or salted fish per se. Consumption of Cantonese-style salted fish during all time periods was significantly associated with nasopharyngeal carcinoma; the association was especially strong during childhood. Past and Recent Salted Fish and Preserved Food Intakes Are Weakly Associated with Nasopharyngeal Carcinoma Risk in Adults in Southern China.  |  Would you like email updates of new search results? Salted fish and other preserved foods presented the weakest risk factor associated with nasopharyngeal carcinoma in all life stages, and therefore may play a smaller role in nasopharyngeal carcinoma occurrence than … 2018 Dec 4;19(1):15. doi: 10.1186/s12867-018-0116-5. Table 2 presents the relationship between dietary factors and NPC risk in the case-control dataset. Thank you for sharing this Cancer Research article. That's probably because the nasopharynx isn't eas… ↵2 To whom requests for reprints should be addressed. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Int J Cancer . Since salted fish is traditionally eaten with rice, part of a staple diet for children, and poor populations of Southern China, these are the populations that are at highest risk of nasopharyngeal cancer. Smoking, alcohol consumption, and exposure to formaldehyde may also result in nasopharyngeal cancer. Then the EBV DNA may instruct the cells of the nasopharynx to divide and grow in an abnormal way. Interviews with 100 cases and 100 controls indicated that salted fish … Diets very high in salt cured meats and fish or pickled foods are more common in some of these places. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Salted fish added to soft rice, a mushy form of rice, is a common food fed to southern Chinese in the weaning and post-weaning period (34). The diet rich in salted fish or meat also increase the risk of developing this cancer. Cantonese-style salted fish and nasopharyngeal cancer Cantonese-style salted fish contains nitrosamines and nitrosamine precursors. Cancer Research Print ISSN: 0008-5472 HHS BMC Mol Biol. Armstrong RW, Imrey PB, Lye MS, Armstrong MJ, Yu MC, Sani S. Int J Epidemiol. Clipboard, Search History, and several other advanced features are temporarily unavailable. Multivariate analyses showed that IgA/VCA was the most important predictor of NPC, and salted fish … Salted fish and nasopharyngeal carcinoma in Malaysia. Not so in southern China. There was no association between nasopharyngeal carcinoma and tobacco, alcohol, or nasal ointments. For instance, eating a diet high in salt-cured fish … Salted fish and nasopharyngeal carcinoma. These foods can be very high in nitrates and nitrites, which react with protein to form nitrosamines. Very rarely does Epstein-Barr virus lead to cancer, which suggests a variety of influencing factors. (11) found a positive association between expo- sure to salted fish … Cancer Research Online ISSN: 1538-7445 SALTED FISH AND NASOPHARYNGEAL CARCINOMA IN SOUTHERN CHINESE. During … High levels of one such nitrosamine, N … Novel Therapies Boosting T Cell Immunity in Epstein Barr Virus-Associated Nasopharyngeal Carcinoma. Consumption of Salted Fish and Other Risk Factors for Nasopharyngeal Carcinoma (NPC) in Tianjin, a Low-Risk Region for NPC in the People's Republic of China ... a Low-Risk Region for NPC in the People's Republic of China, JNCI: Journal of the National Cancer … Avoid taking excessive amounts of salted fish … Soc Sci Med. There is strong evidence that eating high amounts of Cantonese-style salted fish increases the risk of nasopharyngeal cancer. We conducted a case-control study of nasopharyngeal carcinoma among Malaysian Chinese to test inhalants, salted fish consumption, and use of tobacco, alcohol, and nasal ointments as risk factors for the disease. Two hundred fifty incident cases of nasopharyngeal carcinoma under age 35 years in Hong Kong Chinese and an equal number of age- and sex-matched friend controls were interviewed. In a case-control study in Hong Kong, Geser et al. Rates of nasopharyngeal cancer are high in areas where eating salt-cured foods, especially Chinese-style salted fish, is very common. Salted fish Salted fish – Bestofhealthline Chinese-style salted fish is labeled as potentially carcinogenic, and there are studies that link the consumption of this type of fish with nasopharyngeal cancer. The Lancet Salted Fish and Nasopharyngeal Carcinoma PEOPLE of southern Chinese stock are unusually prone to nasopharyngeal carcinoma (NPC); South- East Asia is the principal area where this otherwise rare cancer is encountered.  |  Salted fish and inhalants as risk factors for nasopharyngeal carcinoma in Malaysian Chinese. Interviews with 100 cases and 100 controls indicated that salted fish consumption during childhood was a significant risk factor (relative risk, 3.0; p = 0.04); childhood daily consumption of this food item compared to nonconsumption carried a relative risk of 17.4 [95% confidence interval = (2.7, 111.1)]. Journal of Cancer Research ISSN: 0099-7013 Despite salted fish being a classical risk factor of Nasopharyngeal Carcinoma (NPC), whether secular trends in salted fish consumption worldwide accounted for changes in NPC rates … Cantonese-style Salted Fish as a Cause of Nasopharyngeal Carcinoma: Report of a Case-Control Study in Hong Kong, Clinical and Epidemiological Investigations, Association between Hepatitis C Virus Antibodies and Hepatocellular Carcinoma in Taiwan, Evaluation of Nontumorous Tissue Damage by Transcatheter Arterial Embolization for Hepatocellular Carcinoma, Comparison of Immunoscintigraphy and Computerized Tomography in Identifying Colorectal Cancer: Individual Lesion Analysis, Cancer Epidemiology, Biomarkers & Prevention. Previous Article HEALTH SCREENING IN RESIDENTIAL HOMES. It occurs much more frequently in other parts of the world — specifically Southeast Asia.Nasopharyngeal carcinoma is difficult to detect early. Eat plenty of fresh fruit, green vegetables and other sources of vitamin C to lower your cancer risk. Salted fish and inhalants as risk factors for nasopharyngeal carcinoma in Malaysian Chi… Bakkalci D, Jia Y, Winter JR, Lewis JE, Taylor GS, Stagg HR. ©1986 American Association for Cancer Research. Cantonese-style salted fish is generally made by drying the fish, using less salt and a higher degree of fermentation during the drying process than fish preserved (or salted… Certain genetic inheritance of certain tissues may impact the immune system and cause nasopharyngeal cancer. We conducted a case-control study of nasopharyngeal carcinoma among Malaysian Chinese to test inhalants, salted fish consumption, and use of tobacco, alcohol, and nasal ointments as risk factors for the disease. Studies in Asia have shown that people who eat Chinese cured and salted fish are at an increased risk of nasopha… Chinese salted fish linked to cancer In the United States and most developed countries, the incidence of nasopharyngeal carcinoma (NPC) has dwindled over the past 50 years. Consumption of salted fish, salted vegetables and preserved/cured meat were all risk factors … 2020 Jun 16;21(12):4292. doi: 10.3390/ijms21124292. Matrix association region/scaffold attachment region: the crucial player in defining the positions of chromosome breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells. Certain foods might increase your risk of nasopharyngeal cancer. Do not smoke. Armstrong RW, Imrey PB, Lye MS, Armstrong MJ, Yu MC, Sani S. Nasopharyngeal carcinoma in Malaysian Chinese: salted fish and other dietary exposures. The two risk factors (consumption of salted fish and exposure to smoke and/or dust) were independent of each other. Mothers of cases and controls were interviewed also, if available, to obtain information on childhood events concerning the study subjects. Barrett D, Ploner A, Chang ET, Liu Z, Zhang CX, Liu Q, Cai Y, Zhang Z, Chen G, Huang QH, Xie SH, Cao SM, Shao JY, Jia WH, Zheng Y, Liao J, Chen Y, Lin L, Ernberg I, Adami HO, Huang G, Zeng Y, Zeng YX, Ye W. J Nutr. These chemicals can damage DNA. Nasopharyngeal cancer was diagnosed and determined to be stage III (T3 N0: tumor ... salted-fish consumption in early childhood has been correlated with an unusually high incidence 1. 1983;17(20):1559-67. doi: 10.1016/0277-9536(83)90100-4. 3. 1983 Jun;43 (6):2967-70. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. … Other likely causes include genetic susceptibility, consumption of food (in particular salted fish) containing … Please enable it to take advantage of the complete set of features! Putera I, Ramadhan MG, Anindya S, Sutanto NR, Kurniawan A, Hosea FN, Safitri ED. 2020 Jun;10(1):010405. doi: 10.7189/jogh.10.010405. Limit Your Consumption Of Salted Fish And Pickled Foods: Research shows that a diet rich in salted (or pickled) foods, particularly China-style salted fish, heightens the risk of nasopharyngeal cancer. NIH Nasopharyngeal carcinoma in Malaysian Chinese: occupational exposures to particles, formaldehyde and heat. J Glob Health. 2019 Sep 1;149(9):1596-1605. doi: 10.1093/jn/nxz095. Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis. The relative risk for having Cantonese-style salted fish as one of the first solid foods during weaning was 7.5 (95% confidence limits, 3.9, 14.8), and the relative risk for consuming the food at least once a week compared to less than once a month at age 10 years was 37.7 (95% confidence limits, 14.1, 100.4). Next Article FAMILIAL AND SPORADIC HODGKIN'S DISEASE … USA.gov. Risk factors for Epstein Barr virus-associated cancers: a systematic review, critical appraisal, and mapping of the epidemiological evidence. Chinese-style salted fish intake in early life is considered an established risk factor for nasopharyngeal carcinoma (NPC). Consumption of Cantonese-style salted fish during all time periods was significantly associated with nasopharyngeal carcinoma; the association was especially strong during childhood. Nasopharyngeal cancer is more common in parts of Asia and Northern Africa than it is in Europe. 2000 Dec;29(6):991-8. doi: 10.1093/ije/29.6.991. 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